Five-letter position pattern

5 Letter Words with Y as 2nd and S as 3rd Letter

Five letter words with Y second and S third turn up in puzzles more often than you might expect. Y in the second box acts as a vowel, as in TY, LY, CY and SY openings. S in the third box often sits between a vowel and T, or doubles in words like ISSUE.

20matching five-letter words

Five-letter words with Y in the 2nd and S in the 3rd position

  • bysen
  • byssi
  • cysts
  • hyson
  • lysed
  • lyses
  • lysin
  • lysis
  • lysol
  • lyssa
  • mysel
  • mysid
  • nyssa
  • sysin
  • sysop
  • tyste
  • wyson
  • wysty
  • xysti
  • xysts

How These Words Are Built

Openers to expect include L as in LYSIS, C as in CYSTS and N as in NYSSA. The last two letters are often SA as in NYSSA. A few of these entries are rarer words that mostly appear in Scrabble and other word games, so check them against your word list.

Useful five-letter words

CYSTS, NYSSA, LYSIS, LYSOL and LYSSA are the best known words that fit, so they make sensible first guesses.

  • CYSTS
  • NYSSA
  • LYSIS
  • LYSOL
  • LYSSA

What the Letter Pair Tells You

Y and S are both consonants, so the open boxes usually carry the vowels, as in CYSTS, NYSSA and LYSIS. Most of the familiar words open with a consonant. The fifth box is most often S, A and L, which makes it the quickest place to settle the ending.

A Smart Way to Use Both Letters

The first box is the biggest unknown, and L, C and N are the strongest openers to test. If the opener comes back grey, move to the ending and try S in the fifth box. The fixed Y and S do a lot of the work, so spend your guesses on the three open boxes. For a wider view, see 5 letter words with Y as the 2nd letter and 5 letter words with S as the 3rd letter.

Using These Words in Scrabble

In Scrabble, Y is worth four points and S is worth one point. Knowing words such as CYSTS, NYSSA and LYSIS helps you use both tiles quickly when they land on your rack.

Frequently asked questions

What does S as the third letter tell me

S in the third box often sits between a vowel and T, or doubles in words like ISSUE. CYSTS is a good example.

What should I guess first for this pattern

CYSTS is a strong first choice, because it is a familiar word that also tests C, S and T in the three open boxes.

What are some common 5 letter words with Y as 2nd and S as 3rd letter

CYSTS, NYSSA, LYSIS, LYSOL and LYSSA are among the best known.